Senior Scientist Crystallography


CHARM Therapeutics is a biotech company focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, and our ambition is to revolutionise drug discovery.  CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK.  We are seeking an exceptional protein crystallographer with a passion for scientific innovation.  The successful candidate will join a multidisciplinary, highly collaborative discovery team to invent novel medicines and drive them towards the clinic. 




We are currently seeking an experienced protein crystallographer to join the structural sciences group at CHARM Therapeutics working on high throughput crystallographic structure determination to fully enable and drive multiple SBDD campaigns.




The successful candidate will be expected to meet the following criteria:

  • A PhD level qualification in protein crystallography, or a related discipline, is required.


  • Additional previous experience in an industrial / biotech setting would be preferred. 


  • Familiarity with cloning, expressing and purifying multiple target proteins from recombinant systems (both bacterial and eukaryotic) specifically in oncology, alongside higher molecular weight complexes and integral membrane proteins for structural and biophysical analysis. 


  • Extensive expertise in setting up and optimising vapour diffusion crystallisation experiments.


  • Experience in fragment screening approaches, including crystallographic fragment screening.


  • Expertise in collecting and processing X-ray diffraction data from various synchrotron sources across the world.


  • Ability to solve and refine crystallographic structures including expertise in using CCP4, Global Phasing and Phenix crystallographic software suites.


  • Deep understanding of SM / NCE ligand chemical restraint definition and subsequent ligand co-structure refinement.


  • Demonstrated proficiency in shell scripting and experience in developing pipelines to handle large scale diffraction data processing.


  • Experience with PanDDA approaches for data processing would be beneficial.


  • Proven track record in presenting results (both written and verbal) to internal and external audiences.


What is on Offer


  • The chance to work in a highly collaborative, progressive and intellectually stimulating environment, applying state of the art AI-based techniques to revolutionise drug discovery.


  • Excellent base salaries offered with regular appraisals and reviews.


  • Share options in CHARM Therapeutics through the EMI scheme.


  • Vitality Healthcare, including dental and optical.


  • Gym membership through ‘Better Gym’.


  • Budget for employee development; training courses and conferences.


  • Top of the range Macbook pro and any necessary equipment fully expensed.


  • Fruit and snacks delivered to our offices.


  • Regular team social events.

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